Nowadays, disruptive events increasingly affect supply chain resilience and performance, while limited raw material availability drives global adoption of the Circular Economy paradigm. This study assesses how Circular Economy practices influence supply chain resilience by investigating the joint effect of structural design and operational control parameters through simulation-based analysis integrated with Design of Experiments. We examine five sourcing configurations, namely single-sourcing, double-sourcing, symbiotic-sourcing, closed-loop and circular-sourcing. Results show that structural design emerges as the primary determinant of resilience, shaping how supply chains respond to disruptions. At the same time, supply chain resilience is a dynamic outcome that depends on the alignment of sourcing strategies with operational policies. Overall, the adoption of Circular Economy-based sourcing strengthens absorptive capacity, to the extent that service continuity can be maintained without relying on high safety factors.